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Article

The structural basis for autoinhibition of FLT3 by the juxtamembrane domain.

Molecular cell - 30 Jan 2004

Griffith James, Black James, Faerman Carlos, Swenson Lora, Wynn Michael, Lu Fan, Lippke Judith, Saxena Kumkum

Abstract excerpt

FLT3 is a type III receptor tyrosine kinase that is thought to play a key role in hematopoiesis. Certain classes of FLT3 mutations cause constitutively activated forms of the receptor that are found in significant numbers of patients with acute myelogenous leukemia (AML). The mutations occur either in the activation loop, for example, as point mutations of Asp835 or as internal tandem duplication (ITD) sequences...

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Share to fms-Like Tyrosine Kinase 3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14759363
DOI: 10.1016/s1097-2765(03)00505-7

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The structural basis for autoinhibition of FLT3 by the juxtamembrane domain.PMID 14759363Read ↗

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Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignanciesSemantic proximity Read ↗

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