Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies

15 Apr 2001

Abstract excerpt

Mutations of receptor tyrosine kinases are implicated in the constitutive activation and development of human malignancy. An internal tandem duplication (ITD) of the juxtamembrane (JM) domain-coding sequence of the FLT3 gene (FLT3/ITD) is found in 20% of patients with acute myeloid leukemia (AML) and is strongly associated with leukocytosis and a poor prognosis. On the other hand, mutations of the c-KIT gene,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Lymphocytic Leukemia Research
Share to Mast cells and histamine
Share to PI3K/AKT/mTOR signaling in cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11290608
DOI: 10.1182/blood.v97.8.2434

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignanciesPMID 11290608Read ↗

FLT3 in human hematologic malignancies.Semantic proximity Read ↗

FLT3 mutations in acute myeloid leukemia.Semantic proximity Read ↗

Biology, clinical relevance, and molecularly targeted therapy in acute leukemia with FLT3 mutation.Semantic proximity Read ↗

Deletions in FLT-3 juxtamembrane domain define a new class of pathogenic mutations: case report and systematic analysis.Semantic proximity Read ↗

Identifying and characterizing a novel activating mutation of the FLT3 tyrosine kinase in AML.Semantic proximity Read ↗

Internal tandem duplication mutations in the tyrosine kinase domain of FLT3 display a higher oncogenic potential than the activation loop D835Y mutation.Semantic proximity Read ↗

Identification of a novel type of ITD mutations located in nonjuxtamembrane domains of the FLT3 tyrosine kinase receptor.Semantic proximity Read ↗

The structural basis for autoinhibition of FLT3 by the juxtamembrane domain.Semantic proximity Read ↗

Clinical and molecular features of FLT3 juxtamembrane domain missense mutations in acute myeloid leukaemia.Semantic proximity Read ↗

A new and recurrent activating length mutation in exon 20 of the FLT3 gene in acute myeloid leukemiaSemantic proximity Read ↗

Point mutations in the juxtamembrane domain of FLT3 define a new class of activating mutations in AMLSemantic proximity Read ↗

Clinical significance of FLT3 in leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.