The molecular mechanisms behind activation of FLT3 in acute myeloid leukemia and resistance to therapy by selective inhibitors.

Abstract excerpt

Acute myeloid leukemia is an aggressive cancer, which, in spite of increasingly better understanding of its genetic background remains difficult to treat. Mutations in the FLT3 gene are observed in ≈30% of the patients. Most of these mutations are internal tandem duplications (ITDs) of a sequence...

Topics

• Humans
• Leukemia, Myeloid, Acute
• Mutation
• Protein Kinase Inhibitors
• fms-Like Tyrosine Kinase 3