Article
Pharmacological impact of FLT3 mutations on receptor activity and responsiveness to tyrosine kinase inhibitors.
Biochemical pharmacology - 1 Jan 2021
Marensi Vanessa, Keeshan Karen R, MacEwan David J
Abstract excerpt
Acute myelogenous leukaemia (AML) is an aggressive blood cancer characterized by the rapid proliferation of immature myeloid blast cells, resulting in a high mortality rate. The 5-year overall survival rate for AML patients is approximately 25%. Circa 35% of all patients carry a mutation in the F...
Topics
- Amino Acid Sequence
- Animals
- Benzothiazoles
- Clinical Trials as Topic
- Drug Resistance, Neoplasm
- Humans
- Leukemia, Myeloid, Acute
- Mutation
- Phenylurea Compounds
- Protein Kinase Inhibitors
- Protein Structure, Secondary