Article
FLT3 in human hematologic malignancies.
Leukemia & lymphoma - 1 Aug 2002
Kiyoi Hitoshi, Naoe Tomoki
Abstract excerpt
FLT3, a member of the receptor tyrosine kinase (RTK) class III, is preferentially expressed on the surface of a high proportion of acute myeloid leukemia (AML) and B-lineage acute lymphocytic leukemia (ALL) cells in addition to hematopoietic stem cells, brain, placenta and liver. An interaction of FLT3 and its ligand has been shown to play an important role in the survival, proliferation and differentiation of...
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