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Article

The transcription factor Pap1/Caf3 plays a central role in the determination of caffeine resistance in Schizosaccharomyces pombe.

Molecular genetics and genomics : MGG - 1 Mar 2004

Benko Z, Fenyvesvolgyi C, Pesti M, Sipiczki M

Abstract excerpt

We previously identified four nuclear genes (caf1+-caf4+) in Schizosaccharomyces pombe, mutations in which confer resistance to caffeine and brefeldin A. caf1+, caf2+ and caf4+ were sequenced and found to be identical to the multidrug-resistance/stress-response genes hba1, crm1 and trr1, respectively. Here we show that caf3 is allelic to pap1, which encodes an AP-1-like transcription factor. The allele associated...

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PMID: 14758541
DOI: 10.1007/s00438-003-0967-3

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NES

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The transcription factor Pap1/Caf3 plays a central role in the determination of caffeine resistance in Schizosaccharomyces pombe.PMID 14758541Read ↗

Cloning of caf1+, caf2+ and caf4+ from Schizosaccharomyces pombe: their involvement in multidrug resistance, UV and pH sensitivity.Semantic proximity Read ↗

Caffeine-resistance in fission yeast is caused by mutations in a single essential gene, crm1+.Semantic proximity Read ↗

Schizosaccharomyces pombe cells lacking the Ran-binding protein Hba1 show a multidrug resistance phenotype due to constitutive nuclear accumulation of Pap1.Semantic proximity Read ↗

Caffeine-resistance in S. pombe: mutations in three novel caf genes increase caffeine tolerance and affect radiation sensitivity, fertility, and cell cycle.Semantic proximity Read ↗

bfr1+, a novel gene of Schizosaccharomyces pombe which confers brefeldin A resistance, is structurally related to the ATP-binding cassette superfamily.Semantic proximity Read ↗

Genome-wide screen of genes required for caffeine tolerance in fission yeast.Semantic proximity Read ↗

Brefeldin A sensitivity and resistance in Schizosaccharomyces pombe. Isolation of multiple genes conferring resistance.Semantic proximity Read ↗

Multidrug resistance phenotype conferred by overexpressing bfr2+/pad1+/sks1+ or pap1+ genes and mediated by bfr1+ gene product, a structural and functional homologue of P-glycoprotein in Schizosaccharomyces pombe.Semantic proximity Read ↗

The Schizosaccharomyces pombe mam1 gene encodes an ABC transporter mediating secretion of M-factor.Semantic proximity Read ↗

Loss of RanGEF/Pim1 activity abolishes the orchestration of Ran-mediated mitotic cellular events in S. pombe.Semantic proximity Read ↗

A mutation in the RCC1-related protein pim1 results in nuclear envelope fragmentation in fission yeast.Semantic proximity Read ↗

A mutation in the gene involved in sister chromatid separation causes a defect in nuclear mRNA export in fission yeast.Semantic proximity Read ↗

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