Article
A mutation in the gene involved in sister chromatid separation causes a defect in nuclear mRNA export in fission yeast.
Biochemical and biophysical research communications - 10 Oct 2003
Kalam Azad Abul, Ideue Takashi, Ohshima Yasumi, Tani Tokio
Abstract excerpt
Fission yeast ptr4-1 is one of the mRNA transport mutants that accumulate poly(A)(+) RNA in the nuclei at the nonpermissive temperature. We cloned the ptr4(+) gene and found that it is identical with the cut1(+) gene essential for chromosome segregation during mitosis. ptr4/cut1 has no defects in nucleocytoplasmic transport of a protein, indicative of a specific blockage of mRNA export by this mutation. A mutant...
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