Article
Multidrug resistance phenotype conferred by overexpressing bfr2+/pad1+/sks1+ or pap1+ genes and mediated by bfr1+ gene product, a structural and functional homologue of P-glycoprotein in Schizosaccharomyces pombe.
Bioscience, biotechnology, and biochemistry - 1 Feb 1998
Arioka M, Kouhashi M, Yoda K, Takatsuki A, Yamasaki M, Kitamoto K
Abstract excerpt
We investigated the mechanism of multidrug resistance conferred by overexpression of bfr2+/pad1+/sks1+ or pap1+ genes of Schizosaccharomyces pombe. Overexpression of bfr2+ did not confer multidrug resistance on a pap1-disrupted strain. In a mutant with bfr1+ (a putative membrane transporter which...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Anti-Bacterial Agents
- Antifungal Agents
- Brefeldin A
- Carbazoles
- Cyclopentanes
- Cytochalasin B
- Dactinomycin
- Drug Resistance, Multiple
- Drug Synergism
- Enzyme Inhibitors
- Fungal Proteins
- Gene Expression Regulation, Fungal