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Article

Individual RD1-region genes are required for export of ESAT-6/CFP-10 and for virulence of Mycobacterium tuberculosis.

Molecular microbiology - 1 Jan 2004

Guinn Kristi M, Hickey Mark J, Mathur Sanjeev K, Zakel Kelly L, Grotzke Jeff E, Lewinsohn David M, Smith Sherilyn, Sherman David R

Abstract excerpt

The RD1 genomic region is present in virulent strains of Mycobacterium tuberculosis (MTB), missing from the vaccine strain M. bovis BCG, and its importance to virulence has been established experimentally. Based on in silico analysis, it has been suggested that RD1 may encode a novel secretion system, but the mechanism by which this region affects virulence is unknown. Here we examined mutants disrupted in five...

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Identifiers

PMID: 14756778
DOI: 10.1046/j.1365-2958.2003.03844.x
PMCID: PMC1458497

Genes

CFP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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