Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutually dependent secretion of proteins required for mycobacterial virulence

19 Jul 2005

Abstract excerpt

The ESX-1 locus is a region critical for full virulence in Mycobacterium tuberculosis, which encodes two secreted proteins as well as other genes involved in their secretion. The mechanism of secretion of the two proteins, ESAT-6 and CFP-10, and their function remain unknown. Using proteomic methods to search for additional proteins secreted by the ESX-1 locus, we discovered that a protein encoded by a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacteriophages and microbial interactions
Share to Mycobacterium research and diagnosis
Share to Tuberculosis Research and Epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16030141
DOI: 10.1073/pnas.0504922102

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutually dependent secretion of proteins required for mycobacterial virulencePMID 16030141Read ↗

ESX‐1 secreted virulence factors are recognized by multiple cytosolic AAA ATPases in pathogenic mycobacteriaSemantic proximity Read ↗

A mycobacterium ESX-1-secreted virulence factor with unique requirements for export.Semantic proximity Read ↗

The regulatory functions of ESX-1 substrates, EspE and EspF, are separable from secretionSemantic proximity Read ↗

ESAT-6 Secretion-Independent Impact of ESX-1 Genes espF and espG1 on Virulence of Mycobacterium tuberculosisSemantic proximity Read ↗

Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulatorSemantic proximity Read ↗

ESX secretion system: The gatekeepers of mycobacterial survivability and pathogenesisSemantic proximity Read ↗

WhiB6 is required for the secretion-dependent regulation of ESX-1 substrates in pathogenic mycobacteriaSemantic proximity Read ↗

PPE and PE_PGRS proteins of <i>Mycobacterium marinum</i> are transported via the type VII secretion system ESX‐5Semantic proximity Read ↗

Reconstitution of a minimal ESX-5 type VII secretion system suggests a role for PPE proteins in outer membrane transport of proteinsSemantic proximity Read ↗

Proteo-genetic analysis reveals clear hierarchy of ESX-1 secretion in Mycobacterium marinumSemantic proximity Read ↗

MprAB regulates the espA operon in Mycobacterium tuberculosis and modulates ESX-1 function and host cytokine response.Semantic proximity Read ↗

EsxA and EsxB are secreted by an ESAT-6-like system that is required for the pathogenesis of Staphylococcus aureus infections.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.