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Article

Polymorphism in the RD1 locus and its effect on downstream genes among South Indian clinical isolates of Mycobacterium tuberculosis.

Journal of medical microbiology - 1 Oct 2012

Refaya Ahmed Kabir, Sivakumar Shanmugam, Sundararaman Balaji, Narayanan Sujatha

Abstract excerpt

RD1, the region of difference between the virulent strains of Mycobacterium tuberculosis and Mycobacterium bovis BCG, is the most explored region in terms of mycobacterial virulence and vaccine design. This study found a polymorphic intergenic region between two genes, Rv3870 and Rv3871, in the RD1 region. Sequence analysis revealed a 53 bp repeat element that created a polymorphism among the clinical isolates,...

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PMID: 22723257
DOI: 10.1099/jmm.0.044453-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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