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Article

Inhibition of STAT1 sensitizes renal cell carcinoma cells to radiotherapy and chemotherapy

1 Apr 2012

Abstract excerpt

Renal cell carcinoma is resistant to chemotherapy and radiotherapy. STAT1 is overexpressed in human RCC tissue. Downregulation of STAT1 expression could significantly increase the radiosensitivity in RCC cell lines. To further investigate the function of STAT1 in RCC resistance to chemoradiotherapy, a stable STAT1 knockdown cell line was established. Knockdown of STAT1 led to significant growth suppression in...

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PMID: 22262126
DOI: 10.4161/cbt.19291

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