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Article

STAT1 pathway mediates amplification of metastatic potential and resistance to therapy.

PloS one - 8 Jun 2009

Khodarev Nikolai N, Roach Paul, Pitroda Sean P, Golden Daniel W, Bhayani Mihir, Shao Michael Y, Darga Thomas E, Beveridge Mara G, Sood Ravi F, Sutton Harold G, Beckett Michael A, Mauceri Helena J, Posner Mitchell C, Weichselbaum Ralph R

Abstract excerpt

BACKGROUND: Traditionally IFN/STAT1 signaling is connected with an anti-viral response and pro-apoptotic tumor-suppressor functions. Emerging functions of a constitutively activated IFN/STAT1 pathway suggest an association with an aggressive tumor phenotype. We hypothesized that tumor clones that...

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Source

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Identifiers

PMID: 19503789
DOI: 10.1371/journal.pone.0005821
PMCID: PMC2688034

Genes

STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19503789-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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