Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chk2 activation and phosphorylation-dependent oligomerization.

Molecular and cellular biology - 1 Jun 2002

Xu Xingzhi, Tsvetkov Lyuben M, Stern David F

Abstract excerpt

The tumor suppressor gene CHK2 encodes a versatile effector serine/threonine kinase involved in responses to DNA damage. Chk2 has an amino-terminal SQ/TQ cluster domain (SCD), followed by a forkhead-associated (FHA) domain and a carboxyl-terminal kinase catalytic domain. Mutations in the SCD or FHA domain impair Chk2 checkpoint function. We show here that autophosphorylation of Chk2 produced in a cell-free system...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ataxia Telangiectasia Mutated Proteins
Share to Cell-Free System
Share to Checkpoint Kinase 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme Activation

Share to Genes, Tumor Suppressor

Share to Protein Kinases

Share to Rabbits

Share to Radiation, Ionizing

Source

Open in PubMed Open full text

Identifiers

PMID: 12024051
DOI: 10.1128/MCB.22.12.4419-4432.2002
PMCID: PMC133858

Genes

SCD
ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chk2 activation and phosphorylation-dependent oligomerization.PMID 12024051Read ↗

Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain.Semantic proximity Read ↗

The Chk2 protein kinase.Semantic proximity Read ↗

Exploring the intramolecular phosphorylation sites in human Chk2.Semantic proximity Read ↗

Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2.Semantic proximity Read ↗

Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase.Semantic proximity Read ↗

Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis.Semantic proximity Read ↗

CHK2 kinase--a busy messenger.Semantic proximity Read ↗

Chk2 activates E2F-1 in response to DNA damage.Semantic proximity Read ↗

Characterization of tumor-associated Chk2 mutations.Semantic proximity Read ↗

Reduced expression and impaired kinase activity of a Chk2 mutant identified in human lung cancer.Semantic proximity Read ↗

DNA damage regulates Chk2 association with chromatin.Semantic proximity Read ↗

TTK/hMps1 participates in the regulation of DNA damage checkpoint response by phosphorylating CHK2 on threonine 68.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.