The protein sequence and some intron positions are conserved between the switching gene swi10 of Schizosaccharomyces pombe and the human excision repair gene ERCC1.

doi:10.1093/nar/20.23.6347

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Article

The protein sequence and some intron positions are conserved between the switching gene swi10 of Schizosaccharomyces pombe and the human excision repair gene ERCC1.

Nucleic acids research - 11 Dec 1992

Rödel C, Kirchhoff S, Schmidt H

Abstract excerpt

The switching gene swi10+ has a function in mating-type switching as well as in the repair of radiation damages. We have cloned the genomic swi10+ gene by functional complementation of the switching defect of the swi10-154 mutant. The swi10+ gene is not essential for viability. The DNA sequence revealed an open reading frame of 759 nucleotides interrupted by three introns of 127, 52 and 60 bp, respectively. The...

Topics

Amino Acid Sequence
Base Sequence
Biological Evolution
Blotting, Northern
Cloning, Molecular
Conserved Sequence
DNA Repair
DNA, Fungal
DNA-Binding Proteins
Endonucleases
Fungal Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Fungal

Genes, Mating Type, Fungal

Genes, Switch

Genetic Complementation Test

Humans

Introns

Molecular Sequence Data

Source

Open in PubMed Open full text

Identifiers

PMID: 1475195
DOI: 10.1093/nar/20.23.6347
PMCID: PMC334526

Genes

ERCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1475195-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The protein sequence and some intron positions are conserved between the switching gene swi10 of Schizosaccharomyces pombe and the human excision repair gene ERCC1.PMID 1475195Read ↗

Schizosaccharomyces pombe rad23 is allelic with swi10, a mating-type switching/radioresistance gene that shares sequence homology with human and mouse ERCC1.Semantic proximity Read ↗

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3' splice site recognition in S. cerevisiae does not require base pairing with U1 snRNA.Semantic proximity Read ↗

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