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Article

Effect of gene dose and parental origin on bone histomorphometry in X-linked Hyp mice.

Bone - 1 Jan 2004

Qiu Z Q, Travers R, Rauch F, Glorieux F H, Scriver C R, Tenenhouse H S

Abstract excerpt

X-linked hypophosphatemia (XLH) is characterized by rickets and osteomalacia and arises from mutations in the Phex and PHEX genes in mice (Hyp) and humans, respectively. The present study was undertaken to examine the effect of gene dose on the skeletal phenotype using a histomorphometric approach. Metrical traits (vertebral length, growth plate thickness, cancellous osteoid volume per bone volume, and...

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Share to PHEX Phosphate Regulating Neutral Endopeptidase

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Source

Identifiers

PMID: 14751570
DOI: 10.1016/j.bone.2003.09.004

Genes

PHEX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Effect of gene dose and parental origin on bone histomorphometry in X-linked Hyp mice.PMID 14751570Read ↗

Parental origin of mutant allele does not explain absence of gene dose in X-linked Hyp mice.Semantic proximity Read ↗

Craniofacial abnormalities in mice with X-linked hypophosphatemic genes (Hyp or Gy).Semantic proximity Read ↗

Developmental Expression and Tissue Distribution of Phex Protein: Effect of the <i>Hyp</i> Mutation and Relationship to Bone MarkersSemantic proximity Read ↗

Femoral abnormalities and vitamin D metabolism in X-linked hypophosphatemic (Hyp and Gy) mice.Semantic proximity Read ↗

Dosage effect of a Phex mutation in a murine model of X-linked hypophosphatemia.Semantic proximity Read ↗

Overexpression of human PHEX under the human beta-actin promoter does not fully rescue the Hyp mouse phenotype.Semantic proximity Read ↗

X-linked hypophosphataemia: a homologous phenotype in humans and mice with unusual organ-specific gene dosage.Semantic proximity Read ↗

Craniometric measurements of craniofacial malformations in the X-linked hypophosphatemic (Hyp) mouse on two different genetic backgrounds: C57BL/6J and B6C3H.Semantic proximity Read ↗

Partial rescue of the Hyp phenotype by osteoblast-targeted PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) expression.Semantic proximity Read ↗

New intragenic deletions in the Phex gene clarify X-linked hypophosphatemia-related abnormalities in mice.Semantic proximity Read ↗

Overexpression of Phex in osteoblasts fails to rescue the Hyp mouse phenotype.Semantic proximity Read ↗

The X chromosome deletion in HYP mice extends into the intergenic region but does not include the SAT gene downstream from Phex.Semantic proximity Read ↗

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