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Article

Overexpression of Phex in osteoblasts fails to rescue the Hyp mouse phenotype.

The Journal of biological chemistry - 1 Feb 2002

Liu Shiguang, Guo Rong, Tu Qisheng, Quarles L Darryl

Abstract excerpt

Inactivating mutations of Phex, a phosphate-regulating endopeptidase, cause hypophosphatemia and impaired mineralization in X-linked hypophosphatemia (XLH) and its mouse homologue, Hyp. Because Phex is predominantly expressed in bone and cultured osteoblasts from Hyp mice display an apparent intrinsic mineralization defect, it is thought that reduced expression of Phex in mature osteoblasts is the primary cause...

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Source

Identifiers

PMID: 11713245
DOI: 10.1074/jbc.M107707200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpression of Phex in osteoblasts fails to rescue the Hyp mouse phenotype.PMID 11713245Read ↗

Partial rescue of the Hyp phenotype by osteoblast-targeted PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) expression.Semantic proximity Read ↗

Developmental Expression and Tissue Distribution of Phex Protein: Effect of the <i>Hyp</i> Mutation and Relationship to Bone MarkersSemantic proximity Read ↗

Overexpression of human PHEX under the human beta-actin promoter does not fully rescue the Hyp mouse phenotype.Semantic proximity Read ↗

Evidence for Phex haploinsufficiency in murine X-linked hypophosphatemia.Semantic proximity Read ↗

Hexa-D-arginine treatment increases 7B2•PC2 activity in hyp-mouse osteoblasts and rescues the HYP phenotype.Semantic proximity Read ↗

Coordinated maturational regulation of PHEX and renal phosphate transport inhibitory activity: evidence for the pathophysiological role of PHEX in X-linked hypophosphatemia.Semantic proximity Read ↗

Defective Mineralization in X-Linked Hypophosphatemia Dental Pulp Cell Cultures.Semantic proximity Read ↗

X-linked hypophosphataemia: a homologous disorder in humans and mice.Semantic proximity Read ↗

Cloning and sequencing of human PEX from a bone cDNA library: evidence for its developmental stage-specific regulation in osteoblasts.Semantic proximity Read ↗

A Phex mutation in a murine model of X-linked hypophosphatemia alters phosphate responsiveness of bone cells.Semantic proximity Read ↗

Characterization of Novel PHEX Variants in X-linked Hypophosphatemic Rickets and Genotype-PHEX Activity Correlation.Semantic proximity Read ↗

1,25-(OH)2D3 down-regulates expression of Phex, a marker of the mature osteoblast.Semantic proximity Read ↗

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