Overexpression of human PHEX under the human beta-actin promoter does not fully rescue the Hyp mouse phenotype.

doi:10.1359/JBMR.050212

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Article

Overexpression of human PHEX under the human beta-actin promoter does not fully rescue the Hyp mouse phenotype.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jul 2005

Erben Reinhold G, Mayer Dagmar, Weber Karin, Jonsson Kenneth, Jüppner Harald, Lanske Beate

Abstract excerpt

UNLABELLED: XLH in humans and the Hyp phenotype in mice are caused by inactivating Phex mutations. Overexpression of human PHEX under the human beta-actin promoter in Hyp mice rescued the bone phenotype almost completely, but did not affect phosphate homeostasis, suggesting that different, possibly independent, pathophysiological mechanisms contribute to hyperphosphaturia and bone abnormalities in XLH....

Topics

Actins
Animals
Bone Density
Fibroblast Growth Factor-23
Humans
Hypophosphatemia
Kidney
Mice
Mice, Transgenic
PHEX Phosphate Regulating Neutral Endopeptidase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Phosphates

Promoter Regions, Genetic

Proteins

Tissue Distribution

Transcriptional Activation

Transgenes

Source

Open in PubMed

Identifiers

PMID: 15940367
DOI: 10.1359/JBMR.050212

Genes

PHEX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Overexpression of human PHEX under the human beta-actin promoter does not fully rescue the Hyp mouse phenotype.PMID 15940367Read ↗

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Overexpression of Phex in osteoblasts fails to rescue the Hyp mouse phenotype.Semantic proximity Read ↗

Partial rescue of the Hyp phenotype by osteoblast-targeted PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) expression.Semantic proximity Read ↗

X-linked hypophosphataemia: a homologous disorder in humans and mice.Semantic proximity Read ↗

Characterization of Novel PHEX Variants in X-linked Hypophosphatemic Rickets and Genotype-PHEX Activity Correlation.Semantic proximity Read ↗

The X chromosome deletion in HYP mice extends into the intergenic region but does not include the SAT gene downstream from Phex.Semantic proximity Read ↗

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A Phex mutation in a murine model of X-linked hypophosphatemia alters phosphate responsiveness of bone cells.Semantic proximity Read ↗

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