Article
Use of polymerase chain reaction nad denaturing gradient gel electrophoresis to identify polymorphisms in three exons of dopamine D2 receptor gene in schizophrenic and delusional patients.
Neuropsychobiology - 1 Jan 1992
Catalano M, Nobile M, Novelli E, Smeraldi E
Abstract excerpt
The dopamine D2 receptor gene is a candidate gene for schizophrenia. We screened three exons of this gene for mutations in a large sample of schizophrenics, delusional patients and healthy controls. No structural changes were found, thus suggesting that psychopathology is not related to DNA alter...
Topics
- Adult
- Alleles
- Delusions
- Electrophoresis
- Exons
- Female
- Gene Frequency
- Humans
- Male
- Middle Aged
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic