Article
Development of a high-throughput method for screening the dopamine D2 (DRD2) receptor gene polymorphisms based on the LightCycler system.
Clinical laboratory - 1 Jan 2009
Stefan Prause, Moritz Eidens, Alexander Weise, Weber Matthias, Norbert Dahmen, Annette Wunsch, Thomas Forst, Andreas Pfützner
Abstract excerpt
BACKGROUND: The human dopamine receptor D2 (DRD2) is known to be involved in several mental disorders. A series of studies revealed that the polymorphisms *TaqIA and *C957T are linked to these disorders and might influence drug response. METHODS: Screening methods were established for the *TaqIA and *C957T polymorphisms. In the past, the technique of choice has been the time and resource consuming PCR with...
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