Article
Structural change in dopamine D2 receptor gene in a patient with neuroleptic malignant syndrome.
American journal of medical genetics - 19 Jun 1995
Ram A, Cao Q, Keck P E, Pope H G, Otani K, Addonizio G, McElroy S L, Kaneko S, Redlichova M, Gershon E S
Abstract excerpt
Dysfunction of the dopaminergic system has been suggested as a pathogenic mechanism in neuroleptic malignant syndrome. Therefore, we examined the complete coding sequences of the dopamine D2 receptor (DRD2) gene for structural abnormalities in 12 patients with a history of NMS, including two cases of familial NMS. Mutational analysis was performed by denaturing gradient gel electrophoresis (DGGE), a highly...
Topics
- Adult
- Alleles
- Base Sequence
- Female
- Humans
- Male
- Molecular Sequence Data
- Mutation
- Neuroleptic Malignant Syndrome
- Receptors, Dopamine D2
- Sequence Analysis