Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The influenza B virus nonstructural NS1 protein is essential for efficient viral growth and antagonizes beta interferon induction.

Journal of virology - 1 Feb 2004

Dauber Bianca, Heins Gudrun, Wolff Thorsten

Abstract excerpt

We analyzed the functions of the influenza B virus nonstructural NS1-B protein, both by utilizing a constructed mutant virus (Delta NS1-B) lacking the NS1 gene and by testing the activities of the protein when expressed in cells. The mutant virus replicated to intermediate levels in 6-day-old embryonated chicken eggs that contain an immature interferon (IFN) system, whereas older eggs did not support viral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chick Embryo
Share to Chlorocebus aethiops
Share to Dogs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Influenza B virus

Share to Interferon-beta

Share to Vero Cells

Share to Viral Nonstructural Proteins

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 14747551
DOI: 10.1128/jvi.78.4.1865-1872.2004
PMCID: PMC369500

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The influenza B virus nonstructural NS1 protein is essential for efficient viral growth and antagonizes beta interferon induction.PMID 14747551Read ↗

Double-Stranded RNA Binding of Influenza B Virus Nonstructural NS1 Protein Inhibits Protein Kinase R but Is Not Essential To Antagonize Production of Alpha/Beta InterferonSemantic proximity Read ↗

Multiple Anti-Interferon Actions of the Influenza A Virus NS1 ProteinSemantic proximity Read ↗

Deletion of accessory genes 3a, 3b, 5a or 5b from avian coronavirus infectious bronchitis virus induces an attenuated phenotype both in vitro and in vivoSemantic proximity Read ↗

Amelioration of Influenza Virus Pathogenesis in Chickens Attributed to the Enhanced Interferon-Inducing Capacity of a Virus with a Truncated NS1 GeneSemantic proximity Read ↗

Truncation of the NS1 protein converts a low pathogenic avian influenza virus into a strong interferon inducer in duck cells.Semantic proximity Read ↗

Genetic and phenotypic analysis of reassortants of high growth and low growth strains of influenza B virus.Semantic proximity Read ↗

A recombinant newcastle disease virus with low-level V protein expression is immunogenic and lacks pathogenicity for chicken embryos.Semantic proximity Read ↗

Mutation of influenza A virus PA-X decreases pathogenicity in chicken embryos and can increase the yield of reassortant candidate vaccine virusesSemantic proximity Read ↗

A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in mice.Semantic proximity Read ↗

Influenza virus interferon-inducing particle efficiency is reversed in avian and mammalian cells, and enhanced in cells co-infected with defective-interfering particles.Semantic proximity Read ↗

Influenza B Virus NS1-Truncated Mutants: Live-Attenuated Vaccine ApproachSemantic proximity Read ↗

MDCK cell line with inducible allele B NS1 expression propagates delNS1 influenza virus to high titres.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.