Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Truncation of the NS1 protein converts a low pathogenic avian influenza virus into a strong interferon inducer in duck cells.

Avian diseases - 1 Mar 2010

Soubies Sébastien Mathieu, Volmer Christelle, Guérin Jean-Luc, Volmer Romain

Abstract excerpt

The NS1 protein of influenza A viruses is known as a nonessential virulence factor inhibiting type I interferon (IFN) production in mammals and in chicken cells. Whether NS1 inhibits the induction of type I IFNs in duck cells is currently unknown. In order to investigate this issue, we used reverse genetics to generate a virus expressing a truncated NS1 protein. Using the low pathogenic avian influenza virus...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cells, Cultured
Share to Ducks
Share to Fibroblasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Viral

Share to Influenza A virus

Share to Interferons

Share to Viral Nonstructural Proteins

Share to Virus Replication

Source

Identifiers

PMID: 20521689
DOI: 10.1637/8707-031709-Reg.1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Truncation of the NS1 protein converts a low pathogenic avian influenza virus into a strong interferon inducer in duck cells.PMID 20521689Read ↗

In turkeys, unlike chickens, the non-structural NS1 protein does not play a significant role in the replication and tissue tropism of the H7N1 avian influenza virusSemantic proximity Read ↗

Amelioration of Influenza Virus Pathogenesis in Chickens Attributed to the Enhanced Interferon-Inducing Capacity of a Virus with a Truncated NS1 GeneSemantic proximity Read ↗

NS1-mediated delay of type I interferon induction contributes to influenza A virulence in ferretsSemantic proximity Read ↗

Attenuation of Equine Influenza Viruses through Truncations of the NS1 ProteinSemantic proximity Read ↗

Properties of H7N7 influenza A virus strain SC35M lacking interferon antagonist NS1 in mice and chickensSemantic proximity Read ↗

D2I and F9Y Mutations in the NS1 Protein of Influenza A Virus Affect Viral Replication via Regulating Host Innate Immune Responses.Semantic proximity Read ↗

The NS1 protein of influenza A virus suppresses interferon-regulated activation of antigen-presentation and immune-proteasome pathwaysSemantic proximity Read ↗

A Naturally Occurring Deletion in Its NS Gene Contributes to the Attenuation of an H5N1 Swine Influenza Virus in ChickensSemantic proximity Read ↗

A Naturally Occurring Deletion in the Effector Domain of H5N1 Swine Influenza Virus Nonstructural Protein 1 Regulates Viral Fitness and Host Innate ImmunitySemantic proximity Read ↗

The NS Segment of an H5N1 Highly Pathogenic Avian Influenza Virus (HPAIV) Is Sufficient To Alter Replication Efficiency, Cell Tropism, and Host Range of an H7N1 HPAIVSemantic proximity Read ↗

Differential innate responses of chickens and ducks to low-pathogenic avian influenzaSemantic proximity Read ↗

Strong interferon-inducing capacity of a highly virulent variant of influenza A virus strain PR8 with deletions in the NS1 gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.