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Article

Multiple Anti-Interferon Actions of the Influenza A Virus NS1 Protein

19 Apr 2007

Abstract excerpt

The replication and pathogenicity of influenza A virus (FLUAV) are controlled in part by the alpha/beta interferon (IFN-alpha/beta) system. This virus-host interplay is dependent on the production of IFN-alpha/beta and on the capacity of the viral nonstructural protein NS1 to counteract the IFN system. Two different mechanisms have been described for NS1, namely, blocking the activation of IFN regulatory factor 3...

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Identifiers

PMID: 17442719
DOI: 10.1128/jvi.02581-06

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