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Article

Substrate inhibition of uracil phosphoribosyltransferase by uracil can account for the uracil growth sensitivity of Leishmania donovani pyrimidine auxotrophs.

The Journal of biological chemistry - 11 Oct 2013

Soysa Radika, Wilson Zachary N, Elferich Johannes, Forquer Isaac, Shinde Ujwal, Riscoe Michael K, Yates Phillip A, Ullman Buddy

Abstract excerpt

The pathogenic protozoan parasite Leishmania donovani is capable of both de novo pyrimidine biosynthesis and salvage of pyrimidines from the host milieu. Genetic analysis has authenticated L. donovani uracil phosphoribosyltransferase (LdUPRT), an enzyme not found in mammalian cells, as the focal enzyme of pyrimidine salvage because all exogenous pyrimidines that can satisfy the requirement of the parasite for...

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Identifiers

PMID: 23986453
DOI: 10.1074/jbc.M113.478826
PMCID: PMC3795293

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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