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Article

Synthetase competition and tRNA context determine the in vivo identify of tRNA discriminator mutants.

Journal of molecular biology - 20 Dec 1992

Sherman J M, Rogers K, Rogers M J, Söll D

Abstract excerpt

The discriminator nucleotide (position 73) in tRNA has long been thought to play a role in tRNA identity as it is the only variable single-stranded nucleotide that is found near the site of aminoacylation. For this reason, a complete mutagenic analysis of the discriminator in three Escherichia coli amber suppressor tRNA backgrounds was undertaken; supE and supE-G1C72 glutamine tRNAs, gluA glutamate tRNA and supF...

Topics

Amino Acids
Amino Acyl-tRNA Synthetases
Binding, Competitive
Escherichia coli
Genes, Suppressor
Mutation
Protein Biosynthesis
RNA, Transfer
RNA, Transfer, Gln
RNA, Transfer, Glu
RNA, Transfer, Tyr

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Structure-Activity Relationship

Tetrahydrofolate Dehydrogenase

Source

Identifiers

PMID: 1474577
DOI: 10.1016/0022-2836(92)90314-a

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1474577-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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