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Article

Synthetase competition and tRNA context determine the in vivo identify of tRNA discriminator mutants.

Journal of molecular biology - 20 Dec 1992

Sherman J M, Rogers K, Rogers M J, Söll D

Abstract excerpt

The discriminator nucleotide (position 73) in tRNA has long been thought to play a role in tRNA identity as it is the only variable single-stranded nucleotide that is found near the site of aminoacylation. For this reason, a complete mutagenic analysis of the discriminator in three Escherichia coli amber suppressor tRNA backgrounds was undertaken; supE and supE-G1C72 glutamine tRNAs, gluA glutamate tRNA and supF...

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Source

Identifiers

PMID: 1474577
DOI: 10.1016/0022-2836(92)90314-a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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