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Article

Lack of replication of association findings in complex disease: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's disease.

European journal of human genetics : EJHG - 1 Jun 2001

Prince J A, Feuk L, Sawyer S L, Gottfries J, Ricksten A, Nägga K, Bogdanovic N, Blennow K, Brookes A J

Abstract excerpt

There is considerable enthusiasm for the prospect of using common polymorphisms (primarily single nucleotide polymorphisms; SNPs) in candidate genes to unravel the genetics of complex disease. This approach has generated a number of findings of loci which are significantly associated with sporadic Alzheimer's disease (AD). In the present study, a total of 15 genes of interest were chosen from among the previously...

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Source

Identifiers

PMID: 11436125
DOI: 10.1038/sj.ejhg.5200651

Genes

APBB1
BCHE
BLMH
CTSD
DLST
ESR1
LRP1
MTHFR
NOS3
PSEN1
PSEN2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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