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Article

Tagging single-nucleotide polymorphisms in antioxidant defense enzymes and susceptibility to breast cancer.

Cancer research - 15 Jan 2006

Cebrian Arancha, Pharoah Paul D, Ahmed Shahana, Smith Paula L, Luccarini Craig, Luben Robert, Redman Karen, Munday Hannah, Easton Douglas F, Dunning Alison M, Ponder Bruce A J

Abstract excerpt

It is generally believed that the initiation of breast cancer is a consequence of cumulative genetic damage leading to genetic alterations and provoking uncontrolled cellular proliferation and/or aberrant programmed cell death, or apoptosis. Reactive oxygen species have been related to the etiology of cancer as they are known to be mitogenic and therefore capable of tumor promotion. The aim of this study was to...

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Source

Identifiers

PMID: 16424062
DOI: 10.1158/0008-5472.CAN-05-1857

Genes

TXNRD2
CAT
GPX1
GPX4
GSR
SOD1
SOD2
TXN
TXN2
TXNRD1

Variants

Provenance

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