Article
[Polymorphisms in the oxidative stress-related genes and cancer risk].
Annales Academiae Medicae Stetinensis - 1 Jan 2013
Janicka Anna, Szymańska-Pasternak Jolanta, Bober Joanna
Abstract excerpt
Oxidative damage induced by the generation of reactive oxygen species (ROS) is thought to be related to human cancer aetiology. Oxidative stress can result in DNA damage, including oxidized bases, formation of DNA adducts and DNA strand breaks, as well as lipid peroxidation, protein modification, membrane disruption and mitochondrial damage. The effect of reactive oxygen species is balanced by the antioxidant...
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