Article
Dinitroanilines bind alpha-tubulin to disrupt microtubules.
Molecular biology of the cell - 1 Apr 2004
Morrissette Naomi S, Mitra Arpita, Sept David, Sibley L David
Abstract excerpt
Protozoan parasites are remarkably sensitive to dinitroanilines such as oryzalin, which disrupt plant but not animal microtubules. To explore the basis of dinitroaniline action, we isolated 49 independent resistant Toxoplasma gondii lines after chemical mutagenesis. All 23 of the lines that we examined harbored single point mutations in alpha-tubulin. These point mutations were sufficient to confer resistance...
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