Article
Molecular evidence of widespread benzimidazole drug resistance in Ancylostoma caninum from domestic dogs throughout the USA and discovery of a novel β-tubulin benzimidazole resistance mutation.
PLoS pathogens - 1 Mar 2023
Venkatesan Abhinaya, Jimenez Castro Pablo D, Morosetti Arianna, Horvath Hannah, Chen Rebecca, Redman Elizabeth, Dunn Kayla, Collins James Bryant, Fraser James S, Andersen Erik C, Kaplan Ray M, Gilleard John S
Abstract excerpt
Ancylostoma caninum is an important zoonotic gastrointestinal nematode of dogs worldwide and a close relative of human hookworms. We recently reported that racing greyhound dogs in the USA are infected with A. caninum that are commonly resistant to multiple anthelmintics. Benzimidazole resistance in A. caninum in greyhounds was associated with a high frequency of the canonical F167Y(TTC>TAC) isotype-1 β-tubulin...
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