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Article

A possible model of benzimidazole binding to beta-tubulin disclosed by invoking an inter-domain movement.

Journal of molecular graphics & modelling - 1 Dec 2004

Robinson Mark W, McFerran Neil, Trudgett Alan, Hoey Liz, Fairweather Ian

Abstract excerpt

Although it is well established that benzimidazole (BZMs) compounds exert their therapeutic effects through binding to helminth beta-tubulin and thus disrupting microtubule-based processes in the parasites, the precise location of the benzimidazole-binding site on the beta-tubulin molecule has yet to be determined. In the present study, we have used previous experimental data as cues to help identify this site....

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Identifiers

PMID: 15530823
DOI: 10.1016/j.jmgm.2004.08.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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