Article
A genetic polymorphism of the alpha2-adrenergic receptor increases autonomic responses to stress.
Journal of applied physiology (Bethesda, Md. : 1985) - 1 Jun 2004
Finley J Clayton, O'Leary Michael, Wester Derin, MacKenzie Steven, Shepard Neil, Farrow Stephen, Lockette Warren
Abstract excerpt
We hypothesized that individual differences in autonomic responses to psychological, physiological, or environmental stresses are inherited, and exaggerated autonomic responsiveness may represent an intermediate phenotype that can contribute to the development of essential hypertension in humans over time. alpha(2)-Adrenergic receptors (alpha(2)-ARs), encoded by a gene on chromosome 10, are found in the central...
Topics
- 3' Untranslated Regions
- Animals
- Autonomic Nervous System
- Base Sequence
- CHO Cells
- Chloramphenicol O-Acetyltransferase
- Cricetinae
- DNA Primers
- Female
- Genotype
- Heart Rate
- Humans
- Male
- Molecular Sequence Data