Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Up-regulation and altered distribution of lysyl oxidase in the central nervous system of mutant SOD1 transgenic mouse model of amyotrophic lateral sclerosis.

Brain research. Molecular brain research - 5 Jan 2004

Li Ping-An, He QingPing, Cao Tongyu, Yong Gregory, Szauter Kornelia Molnarne, Fong Keith S K, Karlsson Jenny, Keep Marcus F, Csiszar Katalin

Abstract excerpt

Mutations of the copper-zinc superoxide dismutase (SOD1) gene can result in the development of amyotrophic lateral sclerosis (ALS). The exact cellular mechanisms causing ALS are not known, but oxidative stress is thought to play a prominent role. Lysyl oxidase (LOX) is one of the genes that are known to be up-regulated in ALS patients. In this study, we examined LOX localization in wild type rat and mouse brain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis
Share to Central Nervous System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Hybridization

Share to Mice, Inbred Strains

Share to Microscopy, Confocal

Share to Protein-Lysine 6-Oxidase

Share to Superoxide Dismutase

Share to Superoxide Dismutase-1

Source

Identifiers

PMID: 14741400
DOI: 10.1016/j.molbrainres.2003.10.013

Genes

LOX
SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Up-regulation and altered distribution of lysyl oxidase in the central nervous system of mutant SOD1 transgenic mouse model of amyotrophic lateral sclerosis.PMID 14741400Read ↗

Immunohistochemical study on the distribution of MnSOD in the central nervous system of the transgenic mice expressing a human Cu/Zn SOD mutation.Semantic proximity Read ↗

Transgenic mouse model for familial amyotrophic lateral sclerosis with superoxide dismutase-1 mutationSemantic proximity Read ↗

Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis.Semantic proximity Read ↗

Mutation of superoxide dismutase elevates reactive species: comparison of nitration and oxidation of proteins in different brain regions of transgenic mice with amyotrophic lateral sclerosis.Semantic proximity Read ↗

Restricted expression of mutant SOD1 in spinal motor neurons and interneurons induces motor neuron pathology.Semantic proximity Read ↗

Transcriptional profiling in the lumbar spinal cord of a mouse model of amyotrophic lateral sclerosis: a role for wild-type superoxide dismutase 1 in sporadic disease?Semantic proximity Read ↗

Oxidative stress and antioxidant enzyme upregulation in SOD1-G93A mouse skeletal muscle.Semantic proximity Read ↗

Analysis of the functional effects of a mutation in SOD1 associated with familial amyotrophic lateral sclerosis.Semantic proximity Read ↗

Hypoxic induction of vascular endothelial growth factor is selectively impaired in mice carrying the mutant SOD1 gene.Semantic proximity Read ↗

Axonal transport of mutant superoxide dismutase 1 and focal axonal abnormalities in the proximal axons of transgenic mice.Semantic proximity Read ↗

Metallothionein proteins expression, copper and zinc concentrations, and lipid peroxidation level in a rodent model for amyotrophic lateral sclerosis.Semantic proximity Read ↗

Change in superoxide dismutase 1 protein localization towards mitochondria: an immunohistochemical study in transgenic G93A mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.