Article
Axonal transport of mutant superoxide dismutase 1 and focal axonal abnormalities in the proximal axons of transgenic mice.
Neurobiology of disease - 1 Jul 1998
Borchelt D R, Wong P C, Becher M W, Pardo C A, Lee M K, Xu Z S, Thinakaran G, Jenkins N A, Copeland N G, Sisodia S S, Cleveland D W, Price D L, Hoffman P N
Abstract excerpt
Superoxide dismutase 1 (SOD1), a ubiquitously expressed enzyme, detoxifies superoxide radicals and participates in copper homeostasis. Mutations in this enzyme have been linked to a subset of autosomal dominant cases of familial amyotrophic lateral sclerosis (FALS), a disorder characterized by se...
Topics
- Animals
- Axonal Transport
- Axons
- Humans
- Mice
- Mice, Transgenic
- Motor Neurons
- Mutation
- Neurofilament Proteins
- Neurons, Afferent
- Phosphorylation
- Sciatic Nerve
- Spinal Cord
- Superoxide Dismutase