Cadmium exposure modulates the gut-liver axis in an Alzheimer’s disease mouse model

Abstract excerpt

The human Apolipoprotein E4 (ApoE4) variant is the strongest known genetic risk factor for Alzheimer's disease (AD). Cadmium (Cd) has been shown to impair learning and memory at a greater extent in humanized ApoE4 knock-in (ApoE4-KI) mice as compared to ApoE3 (common allele)-KI mice. Here, we determined how cadmium interacts with ApoE4 gene variants to modify the gut-liver axis. Large intestinal content bacterial...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cannabis and Cannabinoid Research
• Share to Gut microbiota and health
• Share to Heavy Metal Exposure and Toxicity