Article
Association of the transcobalamin II gene 776C → G polymorphism with Alzheimer's type dementia: dependence on the 5, 10-methylenetetrahydrofolate reductase 1298A → C polymorphism genotype.
Annals of clinical biochemistry - 1 Jul 2015
Cascalheira José F, Gonçalves Mónica, Barroso Madalena, Castro Rita, Palmeira Manuela, Serpa André, Dias-Cabral Ana C, Domingues Fernanda C, Almeida Sofia
Abstract excerpt
BACKGROUND: Decreased serum concentrations of vitamin B12 are associated with Alzheimer's type dementia. The transcobalamin II gene (TCN2) 776C → G polymorphism affects transcobalamin II function as a carrier of vitamin B12 and might modify its availability. The association of the TCN2 776C → G polymorphism with Alzheimer's type dementia is unclear and was investigated in the present study. METHODS: Case-control...
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