Article
The Fas promoter polymorphism at position -670 is not associated with late-onset sporadic Alzheimer's disease.
Dementia and geriatric cognitive disorders - 1 Jan 2004
Rosenmann Hanna, Meiner Zeev, Kahana Esther, Aladjem Zoja, Friedman Gideon, Ben-Yehuda Arie, Grenader Tal, Wertman Eli, Abramsky Oded
Abstract excerpt
The Fas antigen is a cell surface receptor-mediating cell apoptosis. Recent studies have demonstrated that Fas-associated apoptosis is involved in the pathogenesis of Alzheimer's disease (AD). Moreover, the Fas gene is located on chromosome 10q24.1, a region of linkage to late-onset AD (LOAD). These two criteria, pathobiological and positional, make the Fas antigen an interesting candidate for an association with...
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