Article
Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer's disease.
Neuroscience letters - 19 Jun 2006
Hamilton Gillian, Samedi Farzana, Knight Jo, Archer Nicola, Foy Catherine, Walter Sarah, Turic Dragana, Jehu Luke, Moore Pamela, Hollingworth Paul, O'Donovan Michael C, Williams Julie, Owen Michael J, Lovestone Simon, Powell John F
Abstract excerpt
The varepsilon4 allele of the APOE locus is the only confirmed risk factor for late-onset Alzheimer's disease (LOAD). The phosphate and tensin homolog (PTEN) gene is both a biological and positional candidate gene for LOAD. Eight polymorphisms spanning this gene were selected from dbSNP and genotyped in pooled DNA samples of both cases and controls. No evidence for association with LOAD was obtained in this study...
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