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Article

HSP70 peptide binding mutants separate antigen delivery from dendritic cell stimulation.

Immunity - 1 Jan 2004

MacAry Paul A, Javid Babak, Floto R Andres, Smith Kenneth G C, Oehlmann Wulf, Singh Mahavir, Lehner Paul J

Abstract excerpt

Microbial heat shock proteins (HSPs) have been implicated in the induction of both the innate and adaptive arms of the immune response. We now show that human dendritic cells (DC) pulsed with peptide-loaded mycobacterial HSP70 complexes generate potent antigen-specific cytotoxic lymphocyte (CTL) responses, which are dependent on an HSP70-stimulated calcium signaling cascade. From the calculated peptide binding...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 14738768
DOI: 10.1016/s1074-7613(03)00357-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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