Article
Phenotypic and functional effects of heat shock protein 90 inhibition on dendritic cell.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2007
Bae Jooeun, Mitsiades Constantine, Tai Yu-Tzu, Bertheau Robert, Shammas Masood, Batchu Ramesh Babu, Li Cheng, Catley Lawrence, Prabhala Rao, Anderson Kenneth C, Munshi Nikhil C
Abstract excerpt
The 90-kDa heat shock protein (Hsp90) plays an important role in conformational regulation of cellular proteins and thereby cellular signaling and function. As Hsp90 is considered a key component of immune function and its inhibition has become an important target for cancer therapy, we here eval...
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