A mycobacterial heat-shock protein-responsive gamma delta T cell clone also responds to the homologous human heat-shock protein: a possible link between infection and autoimmunity.

Abstract excerpt

Prokaryotic and eukaryotic cells respond to a variety of stress conditions by increasing the synthesis of a family of proteins collectively known as heat-shock proteins (HSP). One of these, a 65-kDa HSP that is highly conserved in many bacteria, is a major target of the immune response to mycobacteria. A gamma delta T cell clone from a healthy donor that recognizes not only the 65-kDa mycobacterial HSP but also...

Topics

• Antigen-Presenting Cells
• Autoantibodies
• Cell Separation
• Clone Cells
• Flow Cytometry
• Heat-Shock Proteins
• Humans
• Lymphocyte Activation
• Mycobacterium
• Phenotype
• Receptors, Antigen, T-Cell