Article
Mutant HSP70 reverses autoimmune depigmentation in vitiligo.
Science translational medicine - 27 Feb 2013
Mosenson Jeffrey A, Zloza Andrew, Nieland John D, Garrett-Mayer Elizabeth, Eby Jonathan M, Huelsmann Erica J, Kumar Previn, Denman Cecele J, Lacek Andrew T, Kohlhapp Frederick J, Alamiri Ahmad, Hughes Tasha, Bines Steven D, Kaufman Howard L, Overbeck Andreas, Mehrotra Shikhar, Hernandez Claudia, Nishimura Michael I, Guevara-Patino Jose A, Le Poole I Caroline
Abstract excerpt
Vitiligo is an autoimmune disease characterized by destruction of melanocytes, leaving 0.5% of the population with progressive depigmentation. Current treatments offer limited efficacy. We report that modified inducible heat shock protein 70 (HSP70i) prevents T cell-mediated depigmentation. HSP70i is the molecular link between stress and the resultant immune response. We previously showed that HSP70i induces an...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.