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Article

High-frequency stimulation of the subthalamic nucleus induces a sustained inhibition of serotonergic system via loss of cell phenotype.

Scientific reports - 17 Aug 2022

Alosaimi Faisal, Temel Yasin, Hescham Sarah, Witzig Victoria S, Almasabi Faris, Tan Sonny K H, Jahanshahi Ali

Abstract excerpt

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has become a standard treatment for Parkinson's disease (PD). However, in a considerable number of patients debilitating psychiatric side-effects occur. Recent research has revealed that external stimuli can alter the neurotransmitters' homeostasis in neurons, which is known as "neurotransmitter respecification". Herein, we addressed if...

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PMID: 35978112
DOI: 10.1038/s41598-022-18294-6
PMCID: PMC9385659

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