Article
An asthma-associated genetic variant of STAT6 predicts low burden of ascaris worm infestation.
Genes and immunity - 1 Jan 2004
Peisong G, Yamasaki A, Mao X-Q, Enomoto T, Feng Z, Gloria-Bottini F, Bottini E, Shirakawa T, Sun D, Hopkin J M
Abstract excerpt
Th-2 immune mechanisms are involved in the pathology of asthma and in the protective immune response to parasitic worms. Common upregulating genetic variants of Th-2 immune signalling are risk factors for asthma, and we tested whether they may confer a counteradvantage in protecting against parasitic worms. We examined the intensity of infection by the parasitic worm, Ascaris lumbricoides, by microsopic counting...
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