Article
Effect of polymorphisms on TGFB1 on allergic asthma and helminth infection in an African admixed population.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology - 1 Apr 2017
Costa Ryan Dos Santos, Figueiredo Camila Alexandrina, Barreto Maurıcio Lima, Alcantara-Neves Neuza Maria, Rodrigues Laura Cunha, Cruz Alvaro A, Vergara Candelaria, Rafaels Nicholas, Foster Cassandra, Potee Joseph, Campbell Monica, Mathias Rasika A, Barnes Kathleen C
Abstract excerpt
BACKGROUND: Allergic asthma is a complex disorder that results from a combination of genetic and environmental factors. Studies suggest that helminth infections can activate a regulatory network characterized by the production of regulatory cytokines, such as interleukin 10 and transforming growth factor β1 (TGF-β1) and subsequently protect against immune-mediated diseases, such as asthma. On the other hand,...
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