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Sirtuin 6 maintains epithelial STAT6 activity to support intestinal tuft cell development and type 2 immunity

3 Sept 2022

Abstract excerpt

-dependent deacetylases and has established diverse roles in aging, metabolism and disease. Here, we report that IEC Sirt6 deletion leads to impaired tuft cell development and type 2 immunity in response to helminth infection, thereby resulting in compromised worm expulsion. Conversely, after helminth infection, IEC SIRT6 transgenic mice exhibit enhanced epithelial remodeling process and more efficient worm...

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PMID: 36057627
DOI: 10.1038/s41467-022-32846-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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