WSB1 and IL21R Genetic Variants Are Involved in Th2 Immune Responses to Ascaris lumbricoides.

doi:10.3389/fimmu.2021.622051

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WSB1 and IL21R Genetic Variants Are Involved in Th2 Immune Responses to Ascaris lumbricoides.

Frontiers in immunology - 1 Jan 2021

Carneiro Valdirene Leão, da Silva Hugo Bernardino Ferreira, Queiroz Gerson de Almeida, Veiga Rafael Valente, Oliveira Pablo Rafael Silveira, Carneiro Norma Vilany Queiroz, Pires Anaque de Oliveira, da Silva Raimon Rios, Sena Flavia, Belitardo Emilia, Nascimento Regina, Silva Milca, Marques Cintia Rodrigues, Costa Ryan Dos Santos, Alcantra-Neves Neuza Maria, Barreto Mauricio L, Cooper Philip J, Figueiredo Camila Alexandrina

Abstract excerpt

Genetic and epigenetic factors are considered to be critical for host-parasite interactions. There are limited data on the role of such factors during human infections with Ascaris lumbricoides. Here, we describe the potential role of genetic factors as determinants of the Th2 immune response to A. lumbricoides in Brazilian children. Stool samples were collected from the children to detect A. lumbricoides by...

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PMID: 33692795
DOI: 10.3389/fimmu.2021.622051
PMCID: PMC7937724

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