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Article

Genetic haplotypes of Th-2 immune signalling link allergy to enhanced protection to parasitic worms.

Human molecular genetics - 1 Aug 2007

Moller Maria, Gravenor Mike B, Roberts Stephen E, Sun Dejan, Gao Peisong, Hopkin Julian M

Abstract excerpt

Parasitic worm infection, allergy and asthma involve increased IgE production, eosinophil activity, mucus secretion and smooth muscle reactivity, effected through Th-2 immune signalling. These pathological features of allergic disorder, common in developed countries, appear to be protective features in resistance to parasitic worm infections prevalent in many developing countries. We investigated how genetic...

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PMID: 17519224
DOI: 10.1093/hmg/ddm131

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STAT6

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