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Retinoic acid regulates C/EBP homologous protein expression (CHOP), which negatively regulates myeloid target genes

12 Aug 2004

Abstract excerpt

Retinoic acid (RA) promotes granulocytic differentiation of normal hematopoietic cells and acute promyelocytic leukemia (APL) blasts by transcriptional modulation of myeloid regulatory genes. In this study, we have identified the C/EBP homologous protein (CHOP) as a novel retinoid-responsive gene using a polymerase chain reaction (PCR)-based cDNA subtraction method. All-trans retinoic acid (ATRA) induced a...

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PMID: 15308577
DOI: 10.1182/blood-2003-10-3688

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